Efficacy of N-Acetylcysteine (NAC) Against Malondialdehyde (MDA) Levels in Diabetic Cataracts: In vivo Study

Background: Diabetes mellitus is a systemic condition that affects various organs, including the eyes. N-acetylcysteine ​​(NAC) functions as an antioxidant because it belongs to thiol group synthesis glutathione. However, availability of cysteine ​​in body only 15%, so ​​supplementation can help with oxidative stress in diabetic cataracts. That will prevent reaction lipid peroxidase and formation PUFA lens membrane, which causes damage cells characterized by increase malondialdehyde. This study aims determine comparison malondialdehyde levels lenses cataract rats given or without topical NAC.
 Methods: 36 were divided into control (received streptozotocin) treatment streptozotocin NAC. Intraperitoneal injection was 90 mg/kg BW performed once week for 3 weeks. GDP examination next day after fasted 16 hours from vein. In tail, > 110 mg/dl categorized diabetes. Topical NAC 4 times per At end study, extracted measurement malondialdehyde.
 Results: The mean MDA higher (2.90±0.71nmol/ml) than (2.33±0.38nmol/ml), p<0.05.
 Conclusion: effective reducing lowering better did not receive vivo.